Tsuna is stricken with an embarrassing disease called Skull's disease, a fatal disease that speaks your embarassing moments even after you have died. Unfortunately for Tsuna the disease will kill him in 2 hours if he is not cured. The only person he can ask help from is Doctor Shamal who only cures women. Bianchi lures Shamal around town to get him away from Tsuna so he would die and she and Reborn would return to Italy. While searching and meeting up with Gokudera, Lambo, and Ipin, they catch him. I-Pin becomes embarassed due to Tsuna's skull disease and explodes, separating everyone. With five minutes remaining, Shamal runs into Kyoko and tries to flirt with that. Tsuna drives himself into Dying Will Mode without the bullet but is stopped before he could attack by hearing embarassing secrets from his skull. With two minutes remaining, Shamal cures Tsuna who feels sorry for him after hearing that he only speant three minutes with someone he liked in his life.
